作者
Francisco Campos-Rodriguez, Miguel A Martinez-Garcia, Montserrat Martinez, Joaquin Duran-Cantolla, Monica de la Peña, María J Masdeu, Monica Gonzalez, Felix del Campo, Inmaculada Gallego, Jose M Marin, Ferran Barbe, Jose M Montserrat, Ramon Farre, Spanish Sleep Network
发表日期
2013/1/1
期刊
American journal of respiratory and critical care medicine
卷号
187
期号
1
页码范围
99-105
出版商
American Thoracic Society
简介
Rationale: Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown.
Objectives: To investigate whether OSA is associated with increased cancer incidence in a large clinical cohort.
Methods: A multicenter, clinical cohort study including consecutive patients investigated for suspected OSA between 2003 and 2007 in seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) and percent nighttime with oxygen saturation less than 90% (TSat90) were used as surrogates of OSA severity, both as continuous variables and categorized by tertiles. Cox proportional hazards regression analyses were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for cancer incidence after adjusting for confounding variables.
Measurements and Main Results: A total of 4,910 patients were analyzed (median follow-up, 4.5 …
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F Campos-Rodriguez, MA Martinez-Garcia, M Martinez… - American journal of respiratory and critical care …, 2013