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Systematic reviews and meta-analyses are important tools in evaluating data supporting evidence-based medicine (Ioannidis, 2016). At the same time, results from meta-analyses can also be confusing, misleading, and harmful when the methods are misused or misinterpreted. It is unfortunate that when endeavoring to provide new insights about treatment using a meta-analysis, the recent paper entitled ‘Treatment Outcomes for Anorexia Nervosa: A Systematic Review and Meta-Analysis of Randomized Controlled Trial’(Murray et al., 2018) may have some of these unintended consequences. There were a variety of methodological decisions made when conducting this meta-analysis that limit the value of its conclusions, such as the inclusion of studies with non-comparable interventions and/or controls, use of widely varying assessment end points as end of treatment (EOT), the combining of highly differing …