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We aimed to characterize the nature and magnitude of cognitive decline in a group of adults with amnestic mild cognitive impairment (aMCI) with high and low levels of amyloid-(A) in relation to healthy older adults with low A levels. Healthy older adults and adults with aMCI enrolled in the Australian Imaging, Biomarker, and Lifestyle study, completed the CogState brief battery at baseline and 18 months, and underwent positron emission tomography neuroimaging for A at baseline. In this study, we included adults with MCI who had been classified as having high and low levels of A and healthy older adults who had been classified as having low levels of A. Linear model analyses adjusted for baseline cognitive function indicated that relative to healthy older adults with low A, adults with aMCI and high A showed greater decline in working memory and in verbal and visual episodic memory at 18 months. Adults with …