作者
Toshiki Kuno, Hisato Takagi, Tomo Ando, Takehiro Sugiyama, Satoshi Miyashita, Nelson Valentin, Yuichi J Shimada, Masaki Kodaira, Yohei Numasawa, Alexandros Briasoulis, Alfred Burger, Sripal Bangalore
发表日期
2020/1/28
期刊
Journal of the American College of Cardiology
卷号
75
期号
3
页码范围
273-285
出版商
American College of Cardiology Foundation
简介
Background
Patients on long-term dialysis are at increased risk of bleeding. Although oral anticoagulants (OACs) are recommended for atrial fibrillation (AF) to reduce the risk of stroke, randomized trials have excluded these populations. As such, the net clinical benefit of OACs among patients on dialysis is unknown.
Objectives
This study aimed to investigate the efficacy and safety of OACs in patients with AF on long-term dialysis.
Methods
MEDLINE and EMBASE were searched through June 10, 2019, for studies that investigated the efficacy and safety of different OAC strategies in patients with AF on long-term dialysis. The efficacy outcomes were ischemic stroke and/or systemic thromboembolism, all-cause mortality, and the safety outcome was major bleeding.
Results
This study identified 16 eligible observational studies (N = 71,877) regarding patients on long-term dialysis who had AF. Only 2 of 16 studies …
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T Kuno, H Takagi, T Ando, T Sugiyama, S Miyashita… - Journal of the American College of Cardiology, 2020