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The phenotypes of CAD related to arterial hypertension co-occurrence were analysed in 174 male patients and 117 control men for the associations with the polymorphisms of the MTHFR gene (677C> T and 1298A> C) and the PON1 gene (-108C> T) in relation to age at diagnosis (less or equal and more than 50 years). We noted the increased frequency of the three MTHFR genotypes: CC/AC, CT/AA and CC/CC in the CAD group (65.5%) in comparison to the control group (45.3%), corresponding to the 2.3-fold increased risk of CAD for men with these genotypes (95% CI (1.4-3.7); p= 0.0005). The higher increase in risk of CAD was noted for the younger men (OR= 3.6; 95% CI (1.6-8.3); p= 0.002) and lower for the older (OR= 1.8; 95% CI (1.0-3.4); p= 0.03). In the normotensive men the greater impact on CAD risk had the homozygous genotypes; the 2.3-fold higher risk was associated with MTHFR CC/AC, CC/CC and TT/AA genotypes (95% CI (1.2-4.4); p= 0.01). After adjustment for age, the association between CAD and MTHFR was significant only for the younger normotensive men (OR= 2.8; 95% CI (1.0-8.0); p= 0.04). Additionally, we found that the younger part of the control group was characterized by higher frequency of the low expression PON1-108T allele and PON1-108TT genotype (0.54 and 31.9% respectively) in comparison to the older men (0.41 and 17.1% respectively; p= 0.03).