作者
Henrik Hasle, Todd A Alonzo, Anne Auvrignon, Catherine Behar, Myron Chang, Ursula Creutzig, Alexandra Fischer, Erik Forestier, Alcira Fynn, Oskar A Haas, Jochen Harbott, Christine J Harrison, Nyla A Heerema, Marry M Van Den Heuvel-Eibrink, Gertjan JL Kaspers, Franco Locatelli, Peter Noellke, Sophia Polychronopoulou, Yaddanapudi Ravindranath, Bassem Razzouk, Dirk Reinhardt, Natalia N Savva, Batia Stark, Stefan Suciu, Ichiro Tsukimoto, David K Webb, Dorora Wojcik, William G Woods, Martin Zimmermann, Charlotte M Niemeyer, Susana C Raimondi
发表日期
2007/6/1
期刊
Blood, The Journal of the American Society of Hematology
卷号
109
期号
11
页码范围
4641-4647
出版商
American Society of Hematology
简介
Monosomy 7 (−7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and −7 or del(7q) with or without other cytogenetic aberrations \± other]. Karyotypes included −7 (n = 90), −7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with −7 ± other compared with del(7q) ± other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with −7 ± other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable …
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H Hasle, TA Alonzo, A Auvrignon, C Behar, M Chang… - Blood, The Journal of the American Society of …, 2007