作者
Zahra Hasan, Kiran Iqbal Masood, Shama Qaiser, Erum Khan, Areeba Hussain, Zara Ghous, Unab Khan, Maliha Yameen, Imran Hassan, Muhammad Imran Nasir, Muhammad Farrukh Qazi, Haris Ali Memon, Shiza Ali, Sadaf Baloch, Zulfiqar A Bhutta, Marc Veldhoen, J Pedro Simas, Syed Faisal Mahmood, Kulsoom Ghias, Rabia Hussain
发表日期
2023/9
期刊
Health Science Reports
卷号
6
期号
9
页码范围
e1521
简介
Background and Aims
COVID‐19 vaccinations have reduced morbidity and mortality from the disease. Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have been associated with immune protection. Seroprevalence studies revealed high immunoglobulin G (IgG) antibody levels to SARS‐CoV‐2 in the Pakistani population before vaccinations. We investigated the effect of BBIBP‐CorV vaccination on circulating IgG antibodies and interferon (IFN)‐γ from T cells measured in a cohort of healthy individuals, with respect to age, gender, and history of COVID‐19.
Methods
The study was conducted between April and October 2021. BBIBP‐CorV vaccinated participants were followed up to 24 weeks. Antibodies to SARS‐CoV‐2 Spike protein and its receptor‐binding domain (RBD) were measured. IFNγ secreted by whole blood stimulation of Spike protein and extended genome antigens …
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Z Hasan, KI Masood, S Qaiser, E Khan, A Hussain… - Health Science Reports, 2023