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Celestrus paniculatus were investigated against Alternaria solani, Curvularia lunata, Fusarium sp., Bipolaris sp. and Helminthosporium sp. at different concentrations (1000, 2000, 3000, 4000 and 5000 μg/ml). At 5000 μg/ml crude extract of Tinospora cordifolia is found to be highly effective against Helminthosporium sp. followed by Acorus calamus against Alternaria solani. On the other hand at 5000 ug/ml, Celestrus paniculatus showed better activity against Alternaria solani and Helminthosporium followed by Acorus calamus against Alternaria solani at 4000 ug/ml. At 5000 ug/ml, all the three crude extracts showed least activity against fungus Curvularia lunata and Fusarium sp. except Acorus calamus that showed better activity against Curvularia lunata. The increase in the production of phenolics in the extract can be correlated with the induction of resistance in treated plants against phytopathogenic fungi. HPLC analysis of the crude extract of medicinal plants showed six different phenolic acids (Benzoic acid, Cinnamic acid, Caffeic acid, Ferulic acid, Gallic acid and Tannic acid) present in varying amount. The results of the study provide scientific basis for the use of the plant extract in the future development as antioxidant, antibacterial, antifungal and anti-inflammatory agent.