作者
Andrew H Beaven, Kayla Sapp, Alexander J Sodt
发表日期
2023/6/6
期刊
Biophysical Journal
卷号
122
期号
11
页码范围
2162-2175
出版商
Elsevier
简介
Endo- and exocytosis proceed through a highly strained membrane fusion pore topology regardless of the aiding protein machinery. The membrane's lipid components bias fusion pores toward expansion or closure, modifying the necessary work done by proteins. Cholesterol, a key component of plasma membranes, promotes both inverted lipid phases with concave leaflets (i.e., negative total curvature, which thins the leaflet) and flat bilayer phases with thick, ordered hydrophobic interiors. We demonstrate by theory and simulation that both leaflets of nascent catenoidal fusion pores have negative total curvature. Furthermore, the hydrophobic core of bilayers with strong negative Gaussian curvature is thinned. Therefore, it is an open question whether cholesterol will be enriched in these regions because of the negative total curvature or depleted because of the membrane thinning. Here, we compare all-atom …
学术搜索中的文章
AH Beaven, K Sapp, AJ Sodt - Biophysical Journal, 2023