作者
Alexander N Larcombe, Rachel E Foong, Elizabeth M Bozanich, Luke J Berry, Luke W Garratt, Rosa C Gualano, Jessica E Jones, Lovisa F Dousha, Graeme R Zosky, Peter D Sly
发表日期
2011/9
期刊
Influenza and Other Respiratory Viruses
卷号
5
期号
5
页码范围
334-342
出版商
Blackwell Publishing Ltd
简介
Please cite this paper as: Larcombe et al. (2011) Sexual dimorphism in lung function responses to acute influenza A infection. Influenza and Other Respiratory Viruses 5(5), 334–342.
Background Males are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and females.
Objectives To determine whether sexual dimorphism exists in the physiological/inflammatory responses of weanling and adult BALB/c mice to influenza.
Methods Weanling and adult mice of both sexes were inoculated with influenza A or appropriate control solution. Respiratory mechanics, responsiveness to methacholine (MCh), viral titre and bronchoalveolar lavage (BAL) cellular inflammation/cytokines were measured 4 (acute) and 21 (resolution) days post‐inoculation.
Results Acute infection impaired lung function and induced hyperresponsiveness …
学术搜索中的文章
AN Larcombe, RE Foong, EM Bozanich, LJ Berry… - Influenza and Other Respiratory Viruses, 2011