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Liver damage is a serious and sometimes fatal consequence of long‐term alcohol intake, which progresses from early‐stage fatty liver (steatosis) to later‐stage steatohepatitis with inflammation and fibrosis/necrosis. However, very little is known about earlier stages of liver disruption that may occur in problem drinkers, those who drink excessively but are not dependent on alcohol.

We examined how repeated binge‐like alcohol drinking in C57BL/6 mice altered liver function, as compared with a single binge‐intake session and with repeated moderate alcohol consumption. We measured a number of markers associated with early‐ and later‐stage liver disruption, including liver steatosis, measures of liver cytochrome P4502E1 (CYP2E1) and alcohol dehydrogenase (ADH), alcohol metabolism, expression of cytokine mRNA, accumulation of 4‐hydroxynonenal (4‐HNE) as an indicator of …