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F-BAR domain proteins serve as transient linkers between the cell cortex and the cytoskeleton in multiple biological contexts.  Recent studies have detailed roles for this protein family in endocytosis, cytokinesis, neurotransmission, motility, and cellular morphogenesis.  Here, we review emerging functional information regarding the recently recognized F-BAR domain family and the regulatory mechanisms whereby F-BAR proteins are deployed in diverse processes.