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We sought to determine whether risedronate can preserve cortical bone mass and mechanical properties during long‐term disuse in dogs, assessed by histomorphometry and biomechanics on metacarpal diaphyses. Risedronate slowed cortical thinning and partially preserved mechanical properties, but it was unable to suppress bone loss to the degree seen in other osteoporoses.

Introduction: Disuse induces dramatic bone loss resulting from greatly elevated osteoclastic resorption. Targeting osteoclasts with antiresorptive agents, such as bisphosphonates, should be an effective countermeasure for preventing disuse osteoporosis.

Materials and Methods: Single forelimbs from beagles (5–7 years old, n = 28) were immobilized (IM) for 12 months. Age‐matched, non‐IM dogs served as controls. One‐half the animals received either risedronate (RIS, 1 mg/kg) or vehicle daily …