作者
Anjali Naresh, Weiwen Long, Gregory A Vidal, William C Wimley, Luis Marrero, Carolyn I Sartor, Sian Tovey, Timothy G Cooke, John MS Bartlett, Frank E Jones
发表日期
2006/6/15
期刊
Cancer research
卷号
66
期号
12
页码范围
6412-6420
出版商
American Association for Cancer Research
简介
ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other three members of the EGFR family (i.e., EGFR, ERBB2/HER2/NEU, and ERBB3), which are associated with aggressive forms of human cancers, ERBB4 expression seems to be selectively lost in tumors with aggressive phenotypes. Consistent with this observation, we show that ERBB4 induces apoptosis when reintroduced into breast cancer cell lines or when endogenous ERBB4 is activated by a ligand. We further show that ligand activation and subsequent proteolytic processing of endogenous ERBB4 results in mitochondrial accumulation of the ERBB4 intracellular domain (4ICD) and cytochrome c efflux, the essential and committed step of mitochondrial regulated apoptosis. Our results indicate that 4ICD is functionally similar to BH3-only …
引用总数
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A Naresh, W Long, GA Vidal, WC Wimley, L Marrero… - Cancer research, 2006