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Department of Physiology and Pharmacology, School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel, Department of Biochemistry, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, Department of Chemistry, Beer Sheba University, Beer Sheba, Israel, Department of Polymer Research, Weizman Institute of Science, Rehovot, Israel, Department of Biochemistry, Hadassah Medical School, and Department of Chemistry, Hebrew University, Jerusalem, Israel Received April 17, 1989; Revised Manuscript Received December 26, 1989 abstract: The result of mixing varying concentrations of the nonionic detergent octyl glucoside (OG) with small unilamellar vesicles (SUV) of egg phosphatidylcholine (PC) made by sonication depends on the ratio between OG and PC in the mixedaggregates. When this molar ratio (Re) is lower than 1.4, the detergent partitions between the PC vesicles and the …