作者
Claudia CV Lang, Yael Renert-Yuval, Ester Del Duca, Ana B Pavel, Jianni Wu, Ning Zhang, Celina Dubin, Ashley Obi, Mashkura Chowdhoury, Madeline Kim, Yeriel D Estrada, James G Krueger, Hashim Kaderbhai, George Semango, Peter Schmid-Grendelmeier, Marie-Charlotte Brüggen, John E Masenga, Emma Guttman-Yassky
发表日期
2021/9/1
期刊
Annals of Allergy, Asthma & Immunology
卷号
127
期号
3
页码范围
334-341
出版商
Elsevier
简介
Background
Atopic dermatitis (AD) is a common disease, with particularly high prevalence found in Africa. It is increasingly recognized that patients with AD of different ethnic backgrounds have unique molecular signatures in the skin, potentially accounting for treatment response variations. Nevertheless, the skin profile of patients with AD from Africa is unknown, hindering development of new treatments targeted to this patient population.
Objective
To characterize the skin profile of patients with AD from Africa.
Methods
Gene expression studies, including RNA sequencing (using threshold of fold change of >2 and false discovery rate of <0.05) and real-time polymerase chain reaction, were performed on skin biopsies of Tanzanian patients with moderate-to-severe AD and controls.
Results
Tanzanian AD skin presented robust up-regulations of multiple key mediators of both T helper 2 (TH2) (interleukin 13 [IL-13], IL-10, IL …
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CCV Lang, Y Renert-Yuval, E Del Duca, AB Pavel… - Annals of Allergy, Asthma & Immunology, 2021