查看文章

Persistent breast pain after breast cancer surgery is common with prevalence rates that range from 25% to 80%. Recently, we used growth mixture modeling to identify latent classes (ie, subgroups) of patients with distinct trajectories of worst breast pain scores using a 0-10 numeric rating scale (NRS), reported prior to and monthly for 6 months after surgery. Four subgroups were identified: 126 patients (31.7%) with" No Pain", 173 (43.4%) with" Mild Pain"(NRS of 3 that remained constant), 53 (13.3%) with" Moderate Pain"(NRS of 2 that increased over time), and 46 (11.6%) with" Severe Pain"(NRS of 8 that remained constant). Given the central role of neurotransmitters in nociceptive transmission, we hypothesized that variations in catecholaminergic, gabaergic, and serotonergic genes would be associated with persistent breast pain in these patients. The purpose of this study was to test for associations between …