作者
Sang Ryung Lee, Chan Kwon Jung, Tae Eun Kim, Ja Seong Bae, So Lyung Jung, Yeong Jin Choi, Chang Suk Kang
发表日期
2013/11/1
期刊
Thyroid
卷号
23
期号
11
页码范围
1416-1422
出版商
Mary Ann Liebert, Inc.
简介
Background: The follicular variant of papillary thyroid carcinoma (FVPTC) presents distinct histologic subtypes and molecular genotyping. The preoperative diagnosis of FVPTC through fine-needle aspiration cytology (FNAC) is challenging.
Methods: We reviewed 59 archival thyroid FNAC specimens of surgically confirmed FVPTC according to histologic subtype: encapsulated FVPTC (n=30) and infiltrative FVPTC (n=29). Galectin-3 immunostaining and molecular analyses for BRAF and three RAS genes (NRAS, HRAS, and KRAS) were performed.
Results: FNAC diagnoses of FVPTC included benign (5%), atypia of undetermined significance (19%), follicular neoplasm/suspicious for follicular neoplasm (14%), suspicious for PTC (29%), and PTC (34%). Galectin-3 immunostaining was positive in 50% of FNAC specimens. A BRAF mutation was found only in 14 (24%) tumors with the FNAC diagnosis of PTC or …
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SR Lee, CK Jung, TE Kim, JS Bae, SL Jung, YJ Choi… - Thyroid, 2013