作者
Weihua Meng, HA Deshmukh, NR Van Zuydam, Y Liu, LA Donnelly, K Zhou, Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate Markers for Micro‐and Macro‐Vascular Hard Endpoints for Innovative Diabetes Tools (SUMMIT) Study Group, AD Morris, HM Colhoun, CNA Palmer, BH Smith
发表日期
2015/3
期刊
European journal of pain
卷号
19
期号
3
页码范围
392-399
简介
Background
Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients. The purpose of this study is to identify genetic factors contributing to this type of pain in a general diabetic population.
Method
We accessed the Genetics of Diabetes Audit and Research Tayside (GoDARTS) datasets that contain prescription information and monofilament test results for 9439 diabetic patients, among which 6927 diabetic individuals were genotyped by Affymetrix SNP6.0 or Illumina OmniExpress chips. Cases of neuropathic pain were defined as diabetic patients with a prescription history of at least one of five drugs specifically indicated for the treatment of neuropathic pain and in whom monofilament test result was positive for sensory neuropathy in at least one foot. Controls were individuals who did not have a record of receiving any …
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W Meng, HA Deshmukh, NR Van Zuydam, Y Liu… - European journal of pain, 2015