作者
Helen M Colhoun, D John Betteridge, Paul Durrington, Graham Hitman, Andrew Neil, Shona Livingstone, Valentine Charlton-Menys, Weihang Bao, David A DeMicco, Gregory M Preston, Harshal Deshmukh, Kathryn Tan, John H Fuller
发表日期
2011/9/1
期刊
Diabetes
卷号
60
期号
9
页码范围
2379-2385
出版商
American Diabetes Association
简介
OBJECTIVE
Circulating levels of soluble receptor for advanced glycation end products (sRAGE) likely comprise both a secreted isoform (esRAGE) and wild-type RAGE cleaved from the cell membrane. Both sRAGE and esRAGE have been proposed as biomarkers of cardiovascular disease (CVD), but prospective data are limited. We examined the relationship of sRAGE and esRAGE to incident coronary heart disease (CHD) and stroke in type 2 diabetic patients followed for 3.9 years in a trial of atorvastatin: the Collaborative Atorvastatin Diabetes Study (CARDS).
RESEARCH DESIGN AND METHODS
We used a nested case-control design sampling all incident cases of CVD with available plasma and randomly selecting three control subjects, who were free of CVD throughout follow-up, per case. Analysis was by Cox regression with adjustment for treatment allocation and relevant …
学术搜索中的文章
HM Colhoun, DJ Betteridge, P Durrington, G Hitman… - Diabetes, 2011