作者
N Van Leeuwen, Giel Nijpels, ML Becker, Harshal Deshmukh, K Zhou, BHC Stricker, AG Uitterlinden, Albert Hofman, Esther van’t Riet, CNA Palmer, B Guigas, PE Slagboom, Paul Durrington, RA Calle, A Neil, Graham Hitman, SJ Livingstone, H Colhoun, RR Holman, MI McCarthy, JM Dekker, LM ’t Hart, ER Pearson
发表日期
2012/7
期刊
Diabetologia
卷号
55
页码范围
1971-1977
出版商
Springer-Verlag
简介
Aims/hypothesis
In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia mutated (ATM) gene in multiple additional populations.
Methods
Incident users of metformin selected from the Diabetes Care System West-Friesland (DCS, n = 929) and the Rotterdam Study (n = 182) from the Netherlands, and the CARDS Trial (n = 254) from the UK were genotyped for rs11212617 and tested for an association with both HbA1c reduction and treatment success, defined as the ability to reach the treatment target of an HbA1c ≤7 % (53 mmol/mol). Finally, a meta-analysis including data from literature was performed.
Results
In the DCS cohort, we observed an association between rs11212617 …
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N Van Leeuwen, G Nijpels, ML Becker, H Deshmukh… - Diabetologia, 2012