作者
Masato Hayashi, Takaki Yoshikawa, Junki Mizusawa, Shinji Hato, Yoshiaki Iwasaki, Mitsuru Sasako, Yasuyuki Kawachi, Hiroyasu Iishi, Yasuhiro Choda, Narikazu Boku, Masanori Terashima
发表日期
2024/5/4
期刊
Journal of Gastrointestinal Cancer
页码范围
1-9
出版商
Springer US
简介
Purpose
Post-operative infectious complication (IC) is a well-known negative prognostic factor, while showing neoadjuvant chemotherapy (NAC) may cancel out the negative influence of IC. This analysis compared the clinical impacts of IC according to the presence or absence of NAC in gastric cancer patients enrolled in the phase III clinical trial (JCOG0501) which compared upfront surgery (arm A) and NAC followed by surgery (arm B) in type 4 and large type 3 gastric cancer.
Methods
The subjects were 224 patients who underwent R0 resection out of 316 patients enrolled in JCOG0501. The prognoses of the patients with or without ICs in each arm were investigated by univariable and multivariable Cox regression analyses.
Results
There were 21 (20.0%) IC occurrences in arm A and 15 (12.6%) in arm B. In arm A, the overall survival (OS) of patients with ICs was slightly worse than those without IC (3-year OS, 57.1 …
学术搜索中的文章
M Hayashi, T Yoshikawa, J Mizusawa, S Hato… - Journal of Gastrointestinal Cancer, 2024