查看文章

Absence of an effective Th‐1 response has been demonstrated as a major cause for the disease pathology among patients with visceral leishmaniasis (VL). Defining strategies to prevent the development of Th‐2 response and/or initiate/activate effective Th‐1 response may be of help to reduce the growing incidence of drug unresponsiveness. Adenosine, which is considered as an endogenous anti‐inflammatory agent is generated in injured/inflamed tissues by the enzymatic catabolism of adenosine triphosphate (ATP), and it suppresses inflammatory responses of essentially all immune cells. The extracellular adenosine‐producing pathway comprises two major enzymes CD39 (ATP→ADP→AMP) and CD73 (AMP→Adenosine). In contrast, the adenosine‐degrading pathway contains only one major enzyme adenosine deaminase (ADA). Our study shows high concentration of adenosine in diseased condition …