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An online survey was completed by 1829 New Zealand adults prescribed antidepressants. Only 43% were experiencing self-reported “severe” depression when first prescribed antidepressants. Thus, most prescriptions were for depression that was self-reported as mild or moderate, despite studies suggesting that antidepressants are no more effective than placebo at these levels. General practitioners (GPs) prescribed at lower depression levels than psychiatrists and spent less time with patients. 35% of GPs and 42% of psychiatrists reportedly gave no information about adverse effects. Almost no prescribers gave information about adverse effects in the personal and interpersonal domains, or about withdrawal effects. Closer adherence to evidence-based prescribing and to the principle of informed consent may lead to a reduction in unnecessary, ineffective, and potentially harmful prescribing.