作者
Brian T Garibaldi, Franco R D’Alessio, Jason R Mock, D Clark Files, Eric Chau, Yoshiki Eto, M Bradley Drummond, Neil R Aggarwal, Venkataramana Sidhaye, Landon S King
发表日期
2013/1
期刊
American journal of respiratory cell and molecular biology
卷号
48
期号
1
页码范围
35-43
出版商
American Thoracic Society
简介
Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly understood. Regulatory T cells (Tregs) are important in lung injury resolution. Their role in fibroproliferation is unknown. We sought to identify the role of Tregs in ALI fibroproliferation, using a murine model of lung injury. Wild-type (WT) and lymphocyte-deficient Rag-1−/− mice received intratracheal LPS. Fibroproliferation was characterized by histology and the measurement of lung collagen. Lung fibrocytes were measured by flow cytometry. To dissect the role of Tregs in fibroproliferation, Rag-1−/− mice received CD4+CD25+ (Tregs) or CD4+CD25− Tcells (non-Tregs) at the time of LPS injury. To define the role of the chemokine (C-X-C motif) ligand 12 (CXCL12)–CXCR4 pathway in ALI fibroproliferation, Rag-1−/− mice were treated with …
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BT Garibaldi, FR D'Alessio, JR Mock, DC Files, E Chau… - American journal of respiratory cell and molecular …, 2013