作者
Karolina Skonieczna-Żydecka, Igor Łoniewski, Agata Misera, Ewa Stachowska, Dominika Maciejewska, Wojciech Marlicz, Britta Galling
发表日期
2019/5/1
来源
Psychopharmacology
卷号
236
页码范围
1491-1512
出版商
Springer Berlin Heidelberg
简介
Rationale
Multiple drugs are known to induce metabolic malfunctions, among them second-generation antipsychotics (SGAs). The pathogenesis of such adverse effects is of multifactorial origin.
Objectives
We investigated whether SGAs drive dysbiosis, assessed whether gut microbiota alterations affect body weight and metabolic outcomes, and looked for the possible mechanism of metabolic disturbances secondary to SGA treatment in animal and human studies.
Methods
A systematic literature search (PubMed/Medline/Embase/ClinicalTrials.gov/PsychInfo) was conducted from database inception until 03 July 2018 for studies that reported the microbiome and weight alterations in SGA-treated subjects.
Results
Seven articles reporting studies in mice (experiments = 8) and rats …
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K Skonieczna-Żydecka, I Łoniewski, A Misera… - Psychopharmacology, 2019