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This paper presents our experience with developing a portable wireless medical sensor device. We use National Instruments (NI) devices and LabView for measurements studying fatigue of patients suffering multiple sclerosis (MS). Fatigue is a very frequent symptom perceived by MS patients, but the disease mechanism is poorly understood. Many efforts have been made to increase the understanding of this complex phenomenon. It has been found that fatigue might be associated with abnormalities in various anatomical brain areas. Also some secondary factors, not directly related to the disease, such as depression, sleep disorder, severe pain, use of medication and psychological factors might be of importance. However, the relationship with physiological parameters and motion activities in MS patients with fatigue across time are still unknown. Therefore, we hypothesize that we could provide a new assessment …