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Background: Pasireotide is a multireceptor-targeted somatostatin analogue that predominantly binds to somatostatin receptor subtype 5 (SSTR5) and provides sustained control of urinary free cortisol (UFC) levels in some patients with Cushing’s disease (CD). Cabergoline is a dopamine D2 receptor agonist with efficacy in some patients with CD. Most corticotropinomas co-express SSTR5 and D2, providing rationale for combination treatment with pasireotide and cabergoline. Results are reported from a Phase II study of pasireotide alone or combined with cabergoline in patients with CD.

Methods: Open-label, multicentre, non-comparative study. Patients with persistent/recurrent or de novo (if not surgical candidates) CD who were pasireotide-untreated at screening were enrolled. Patients initiated treatment with pasireotide (subcutaneous) 0.6 mg bid. If mean UFC (mUFC; from two consecutive 24h collections …