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Essential oils are obtained from vegetal material and present antibacterial activities, antioxidant, antiviral, antifungal properties and may replace the use of chemotherapeutics for treating and prophylaxis in fish farm. The objective of this study was to verify the influence of essential oil of Mentha piperita in the prevention of Streptococcus in Nile tilapia. A total of 300 fish with approximately 5 g were divided into 20 tanks with 15 fish each were fed diet supplemented with essential oil at concentrations of Mentha _0.075%; Mentha _0.125%; Mentha _0.25% and two controls (commercial feed and feed+cereal alcohol) in quadruplicate, during 50 days. At the end of the supplementation period, four fish from each experimental unit were collected for hemato-immunological analysis and the rest of the animals were challenged against Streptococcus agalactiae intraperitoneally. During seven days after infection, the fish were …