作者
Mehdi Mirzaii, Sanaz Jamshidi, Maryam Zamanzadeh, Masoud Marashifard, Seyed Ali Asghar Malek Hosseini, Mehri Haeili, Fariba Jahanbin, Fariba Mansouri, Davood Darban-Sarokhalil, Seyed Sajjad Khoramrooz
发表日期
2018/6/1
期刊
Journal of Global Antimicrobial Resistance
卷号
13
页码范围
197-200
出版商
Elsevier
简介
Objectives
Fluoroquinolones (FQs) are recommended as the drugs of choice for the empirical treatment of urinary tract infections (UTIs). This study investigated the molecular determinants of FQ resistance in Escherichia coli and Klebsiella pneumoniae isolates in Iran.
Methods
A total of 364 clinical isolates of E. coli (n = 144) and K. pneumoniae (n = 220) were collected from patients with UTI. Susceptibility of the isolates to ciprofloxacin, levofloxacin, gatifloxacin and nalidixic acid was evaluated by disk diffusion. The presence of qnrA, qnrB and qnrS genes was assessed by PCR. Nucleotide sequences of the gyrA and parC genes were determined.
Results
Eighty-seven (60.4%) and 15 (6.8%) E. coli and K. pneumoniae isolates, respectively, were resistant to at least one of the tested FQs. Plasmid-mediated quinolone resistance (PMQR) genes were detected in 12.6% and 60.0% of FQ-resistant E. coli and K …
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M Mirzaii, S Jamshidi, M Zamanzadeh, M Marashifard… - Journal of Global Antimicrobial Resistance, 2018