作者
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott, Ulrich Schüller, Sridharan Gururangan, Roger McLendon, Darell Bigner, Maryam Fouladi, Keith L Ligon, Scott L Pomeroy, Sandra Dunn, Joanna Triscott, Nada Jabado, Adam Fontebasso, David TW Jones, Marcel Kool, Matthias A Karajannis, Sharon L Gardner, David Zagzag, Sofia Nunes, José Pimentel, Jaume Mora, Eric Lipp, Andrew W Walter, Marina Ryzhova, Olga Zheludkova, Ella Kumirova, Jad Alshami, Sidney E Croul, James T Rutka, Cynthia Hawkins, Uri Tabori, Kari-Elise T Codispoti, Roger J Packer, Stefan M Pfister, Andrey Korshunov, Michael D Taylor
发表日期
2013/11/1
期刊
The lancet oncology
卷号
14
期号
12
页码范围
1200-1207
出版商
Elsevier
简介
Background
Recurrent medulloblastoma is a therapeutic challenge because it is almost always fatal. Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We sought to delineate subgroup-specific differences in medulloblastoma recurrence patterns.
Methods
We retrospectively identified a discovery cohort of all recurrent medulloblastomas at the Hospital for Sick Children (Toronto, ON, Canada) from 1994 to 2012 (cohort 1), and established molecular subgroups using a nanoString-based assay on formalin-fixed paraffin-embedded tissues or frozen tissue. The anatomical site of recurrence (local tumour bed or leptomeningeal metastasis), time to recurrence, and survival after recurrence were assessed in a subgroup-specific manner. Two independent, non-overlapping cohorts (cohort 2: samples from patients with recurrent medulloblastomas from 13 centres worldwide, obtained …
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V Ramaswamy, M Remke, E Bouffet, CC Faria… - The lancet oncology, 2013