作者
Damien Faury, André Nantel, Sandra E Dunn, Marie-Christine Guiot, Takrima Haque, Péter Hauser, Miklós Garami, László Bognár, Zoltán Hanzély, Pawel P Liberski, Enrique Lopez-Aguilar, Elvis T Valera, Luis G Tone, Anne-Sophie Carret, Rolando F Del Maestro, Martin Gleave, Jose-Luis Montes, Torsten Pietsch, Stephen Albrecht, Nada Jabado
发表日期
2007/4/1
期刊
Journal of Clinical Oncology
卷号
25
期号
10
页码范围
1196-1208
出版商
American Society of Clinical Oncology
简介
Purpose
Pediatric glioblastoma (pGBM) is a rare, but devastating brain tumor. In contrast to GBM in adults (aGBM), little is known about the mechanisms underlying its development. Our aim is to gain insight into the molecular pathways of pGBM.
Materials and Methods
Thirty-two pGBM and seven aGBM samples were investigated using biochemical and transcriptional profiling. Ras and Akt pathway activation was assessed through the phosphorylation of downstream effectors, and gene expression profiles were generated using the University Health Network Human 19K cDNA arrays. Results were validated using real-time polymerase chain reaction and immunohistochemistry and compared with existing data sets on aGBM.
Results
There are at least two subsets of pGBM. One subset, associated with Ras and Akt pathway activation, has very poor prognosis and exhibits …
引用总数
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D Faury, A Nantel, SE Dunn, MC Guiot, T Haque… - Journal of Clinical Oncology, 2007