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Results: Mean dosages of 157 mg (range 70-340) and 180 mg (60-400) propofol were administered for colonoscopy and EGD procedures, respectively. No episodes of apnea occurred. The oxygen saturation fell below 90% for short periods of time in 11 patients (3.7%). Three patients required a temporary increase in oxygen delivery. No assisted ventilation was necessary. In 22 patients (7.3%), the mean blood pressure temporarily decreased below 50 mmHg. Two patients received a 500-ml infusion of normal saline.

Conclusions: Propofol can be safely administered for sedation during colonoscopy and esophagogastroduodenoscopy by nonanesthetists who are familiar with the pharmacological properties and use of this drug.