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Renewable approaches involving the use of natural materials for pollutant removal from wastewaters can offer a favorable solution fitting well with the definition of sustainability. Materials from biological origin (Bean, Moringa, Maize, etc.) have been investigated for their potential use for wastewater treatment. Interestingly, cactus, an abundant plant, offers various options for the treatment of wastewater. The present paper reviews wastewater treatment technologies that may involve cactus. This biomaterial can be involved as coagulant/flocculant, as biosorbent and as packed material for biofilter. Also, cactus may offer enzymatic system useful for the transformation of toxic textile dyes. The results obtained in the depollution of wastewaters using various cactus preparations showed very high and promising pollutant removal efficiency. Generally, cactus reduced significantly many wastewater parameters (turbidity, COD, heavy metal, conductivity, salinity, etc.). Consequently, for many accessibility criteria (composition, properties, abundant, non-toxic, etc.) cactus may be useful material for wastewater treatment making it appropriate for regions of the world, where cactus is available.