作者
Isabel L Jackson, Rada Pavlovic, Allen A Alexander, Caroline Q Connors, Diana Newman, Javed Mahmood, John Eley, Adam J Harvey, Michael D Kaytor, Zeljko Vujaskovic
发表日期
2019/10/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
105
期号
2
页码范围
400-409
出版商
Elsevier
简介
Purpose
To assess whether BIO 300, a synthetic genistein nanosuspension, improves the therapeutic index in prostate cancer treatment by preventing radiation-induced erectile dysfunction (ED) without reducing tumor radiosensitivity.
Methods and Materials
Male Sprague-Dawley rats were exposed to 25 Gy of 220-kV prostate-confined x-rays. Animals were randomized to receive sham radiation therapy (RT), RT alone, RT with daily BIO 300 at 2 experimental dosing regimens, or RT with daily genistein. Erectile response was evaluated over time. Penile shaft tissue was harvested for histologic analyses. Murine xenograft studies using prostate cancer cell lines determined the effects of BIO 300 dosing on RT efficacy.
Results
Prostate-confined RT significantly decreased apomorphine-induced erectile response (P < .05 vs sham RT). Erection frequency in animals receiving prophylactic treatment with BIO 300 starting 3 …
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IL Jackson, R Pavlovic, AA Alexander, CQ Connors… - International Journal of Radiation Oncology* Biology …, 2019