作者
Paul Muntner, Lisandro D Colantonio, Mary Cushman, David C Goff, George Howard, Virginia J Howard, Brett Kissela, Emily B Levitan, Donald M Lloyd-Jones, Monika M Safford
发表日期
2014/4/9
期刊
Jama
卷号
311
期号
14
页码范围
1406-1415
出版商
American Medical Association
简介
Importance
The American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort risk equations were developed to estimate atherosclerotic cardiovascular disease (CVD) risk and guide statin initiation.
Objective
To assess calibration and discrimination of the Pooled Cohort risk equations in a contemporary US population.
Design, Setting, and Participants
Adults aged 45 to 79 years enrolled in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study between January 2003 and October 2007 and followed up through December 2010. We studied participants for whom atherosclerotic CVD risk may trigger a discussion of statin initiation (those without clinical atherosclerotic CVD or diabetes, low-density lipoprotein cholesterol level between 70 and 189 mg/dL, and not taking statins; n = 10 997).
Main Outcomes and Measures
Predicted risk and observed adjudicated …
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