作者
Zhuang Li, Chun-Xia Yi, Saeed Katiraei, Sander Kooijman, Enchen Zhou, Chih Kit Chung, Yuanqing Gao, José K van den Heuvel, Onno C Meijer, Jimmy FP Berbée, Marieke Heijink, Martin Giera, Ko Willems van Dijk, Albert K Groen, Patrick CN Rensen, Yanan Wang
发表日期
2018/7/1
期刊
Gut
卷号
67
期号
7
页码范围
1269-1279
出版商
BMJ Publishing Group
简介
Objective
Butyrate exerts metabolic benefits in mice and humans, the underlying mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite and energy expenditure, and to what extent these two components contribute to the beneficial metabolic effects of butyrate.
Design
Acute effects of butyrate on appetite and its method of action were investigated in mice following an intragastric gavage or intravenous injection of butyrate. To study the contribution of satiety to the metabolic benefits of butyrate, mice were fed a high-fat diet with butyrate, and an additional pair-fed group was included. Mechanistic involvement of the gut-brain neural circuit was investigated in vagotomised mice.
Results
Acute oral, but not intravenous, butyrate administration decreased food intake, suppressed the activity of orexigenic neurons that express neuropeptide Y in the hypothalamus, and decreased neuronal …
学术搜索中的文章
Z Li, CX Yi, S Katiraei, S Kooijman, E Zhou, CK Chung… - Gut, 2018