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Background: Gastric cancer is a life threatening disease. Recent studies have shown that Rosa Damascene possesses noticeable biological effects on the human body. This study, investigates the anticancer effect of Rosa Damascena on gastric cancer cell line MKN45.

Methods: Microscopic studies and MTT assay were used to examine morphological alteration, and cell survival of the cancer cells while exposing to differentvolumes of the essential oilrespectively. In addition, flow cytometry was applied to determine the cell death mechanism of the gastric cancer treated with the essential oil.

Results: The findings indicate that Rosa Damascena essential oil affects gastric cancer cells in two distinctive ways: the soluble phase increases cell viability, while the vapor phase decreases cellsurvival. Moreover, flow cytometry analysis revealed that apoptosis is the main mechanism accompanied with cell death.

Conclusion: Consequently, Rosa Damascena essential oil can be used as a potent anticancer agent in the future. However, more evaluation of this essential oil is still needed to elicit its effectivebiological activities.