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The global agriculture system remains vulnerable to several kinds of spatio-temporal abiotic and biotic stressors. At the molecular and physiological levels, the elimination of challenges associated with these stressors in plants has been intensively explored. The plants appear to have evolved with a multitude of physio-biochemical survival strategies, including a central signaling cross-talk channel that allows the plant to arbitrate between active growth and defensive pathways. Furthermore, exogenous administration of micronutrients such as silicon (Si) and selenium (Se) has been shown to improve plant defense responses under stressful situations. These micro-nutrients exhibited a large number of physio-biochemical responses throughout various plant systems and were found associated with pathways of stress signaling cross-talk. Several studies had provided pieces of evidence for the potential role of Si/Se in …