作者
C Moeller, D Oren, G Rubinstein, D Lotan, S Slomovich, K Clerkin, J Fried, J Raikhelkar, Y Mehlman, E Lin, S Lee, A Kleet, K Oh, V Topkara, EM DeFilippis, D Majure, F Latif, N Uriel, G Sayer
发表日期
2023/4/1
期刊
The Journal of Heart and Lung Transplantation
卷号
42
期号
4
页码范围
S234
出版商
Elsevier
简介
Purpose
Donor-derived cell-free DNA (dd-cfDNA) has emerged as a reliable, noninvasive method for the detection of allograft rejection in heart transplantation (HT) patients. dd-cfDNA is widely used in HT, but its utility in multiorgan transplants (HT + another organ) is unknown. We describe the experience using dd-cfDNA in multiorgan transplant patients.
Methods
Retrospective review of all HT patients transplanted between 1998-2022 at our center that had at least one dd-cfDNA collected between 5/2020 and 8/2022. Patients that had multiorgan transplant were identified and enrolled to this study. dd-cfDNA percentages were quantified and correlated with allograft rejection. The dd-cfDNA variability score was calculated by the variance/mean test value per person. Acute cellular rejection (ACR) was defined as ISHLT grade ≥ 2R and antibody mediated rejection (AMR) > pAMR0.
Results
Of 654 HT patients with dd …
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C Moeller, D Oren, G Rubinstein, D Lotan, S Slomovich… - The Journal of Heart and Lung Transplantation, 2023