作者
D Lotan, R Park, G Rubinstein, C Moeller, EM DeFilippis, K Oh, S Slomovich, D Oren, E Lin, K Clerkin, F Latif, P Colombo, M Yuzefpolskaya, V Topkara, J Kim, D Majure, G Sayer, W Jonathan, N Uriel
发表日期
2023/4/1
期刊
The Journal of Heart and Lung Transplantation
卷号
42
期号
4
页码范围
S225
出版商
Elsevier
简介
Purpose
Undiagnosed chronic antibody mediated rejection (cAMR) is a concern for heart transplantation (HT) recipients who have elevated donor-specific antibody (DSA) levels and/or graft dysfunction but a negative endomyocardial biopsy (EMB). Donor-derived cell-free DNA (dd-cfDNA) and cardiac magnetic resonance (CMR) imaging may be used to provide diagnostic clarity in these cases. We evaluated the utility of CMR and dd-cfDNA in patients suspected to have cAMR
Methods
HT recipients from 2000-2022 with DSA and/or graft dysfunction (TTE; LVEF<40%) without evidence of rejection by EMB who underwent CMR were included. Dd-cfDNA levels and adverse outcomes were included. CMR (1.5T) was performed using a standardized protocol: LV geometry/function was quantified on (SSFP) cine-CMR; tissue characterization included parametric T2 mapping for edema/inflammation assessment, pre- and …
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D Lotan, R Park, G Rubinstein, C Moeller… - The Journal of Heart and Lung Transplantation, 2023