作者
Mary Ellen McCann, Jurgen C de Graaff, Liam Dorris, Nicola Disma, Davinia Withington, Graham Bell, Anneke Grobler, Robyn Stargatt, Rodney W Hunt, Suzette J Sheppard, Jacki Marmor, Gaia Giribaldi, David C Bellinger, Penelope L Hartmann, Pollyanna Hardy, Geoff Frawley, Francesca Izzo, Britta S von Ungern Sternberg, Anne Lynn, Niall Wilton, Martin Mueller, David M Polaner, Anthony R Absalom, Peter Szmuk, Neil Morton, Charles Berde, Sulpicio Soriano, Andrew J Davidson, Sarah Arnup, Katherine Lee, Rod W Hunt, Gillian D Ormond, Michael J Takagi, Kaitlyn Taylor, Stephanie Malarbi, Melissa Doyle, Philip Ragg, David Costi, Britta von Ungern-Sternberg, Niall C Wilton, Graham Knottenbelt, Koto Furue, Hélène Gagnon, Leila Mameli, Alessio Pini Prato, Girolamo Mattioli, Andrea Wolfler, Stefania M Bova, Arianna Krachmalnicoff, Claudia Guuva, Desiree BM van der Werff, Jose TDG van Gool, Kim van Loon, Cor J Kalkman, Anneloes L van Baar, Frouckje M Hoekstra, Martin Volkers, Martine Oostra, Neil S Morton, Jaycee Pownall, Jack Waldman, Ruth Hind, Joseph D Symonds, Oliver Bagshaw, Navil Sethna, Pete Kovatsis, Joseph Cravero, David Bellinger, Iskra Ivanova, Agnes Hunyady, Shilpa Verma, David Polaner, Joss Thomas, Denisa Haret, Jeffrey Steiner, Brian Kravitz, Alan Farrow-Gillespie, Santhanam Suresh, Stephen Hays, Andreas Taenzer, Lynne Maxwell, Robert Williams
发表日期
2019/2/16
期刊
The Lancet
卷号
393
期号
10172
页码范围
664-677
出版商
Elsevier
简介
Background
In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have found no evidence for an association. We aimed to establish whether general anaesthesia in early infancy affects neurodevelopmental outcomes.
Methods
In this international, assessor-masked, equivalence, randomised, controlled trial conducted at 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and New Zealand, we recruited infants of less than 60 weeks' postmenstrual age who were born at more than 26 weeks' gestation and were undergoing inguinal herniorrhaphy, without previous exposure to general …
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ME McCann, JC De Graaff, L Dorris, N Disma… - The Lancet, 2019