作者
Su Ryon Shin, Claudio Zihlmann, Mohsen Akbari, Pribpandao Assawes, Louis Cheung, Kaizhen Zhang, Vijayan Manoharan, Yu Shrike Zhang, Mehmet Yüksekkaya, Kai‐tak Wan, Mehdi Nikkhah, Mehmet R Dokmeci, Xiaowu Tang, Ali Khademhosseini
发表日期
2016/7
期刊
Small
卷号
12
期号
27
页码范围
3677-3689
简介
Biomaterials currently used in cardiac tissue engineering have certain limitations, such as lack of electrical conductivity and appropriate mechanical properties, which are two parameters playing a key role in regulating cardiac cell behavior. Here, the myocardial tissue constructs are engineered based on reduced graphene oxide (rGO)‐incorporated gelatin methacryloyl (GelMA) hybrid hydrogels. The incorporation of rGO into the GelMA matrix significantly enhances the electrical conductivity and mechanical properties of the material. Moreover, cells cultured on composite rGO‐GelMA scaffolds exhibit better biological activities such as cell viability, proliferation, and maturation compared to ones cultured on GelMA hydrogels. Cardiomyocytes show stronger contractility and faster spontaneous beating rate on rGO‐GelMA hydrogel sheets compared to those on pristine GelMA hydrogels, as well as GO‐GelMA hydrogel …
引用总数
201720182019202020212022202320242743607970766437