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The field of proton lung MRI is advancing on a variety of fronts. In the realm of functional imaging, it is now possible to use arterial spin labeling (ASL) and oxygen‐enhanced imaging techniques to quantify regional perfusion and ventilation, respectively, in standard units of measurement. By combining these techniques into a single scan, it is also possible to quantify the local ventilation–perfusion ratio, which is the most important determinant of gas‐exchange efficiency in the lung. To demonstrate potential for accurate and meaningful measurements of lung function, this technique was used to study gravitational gradients of ventilation, perfusion, and ventilation–perfusion ratio in healthy subjects, yielding quantitative results consistent with expected regional variations.

Such techniques can also be applied in the time domain, providing new tools for studying temporal dynamics of lung function. Temporal ASL …