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Enterovirus infections are generally acute and rapidly cleared by the host immune response. Enteroviruses can at times persist in immunologically intact individuals after the rise of the type‐specific neutralizing immune response. The mechanism of enterovirus persistence was shown in group B coxsackieviruses (CVB) to be due to naturally‐occurring deletions at the 5′ terminus of the genome which variably impact the stem‐loop secondary structure called domain I. These deletions result in much slower viral replication and a loss of measurable cytopathic effect when such 5′ terminally deleted (TD) viruses are assayed in cell culture. The existence and persistence of CVB‐TD long after the acute phase of infection has been documented in hearts of experimentally inoculated mice and naturally infected humans but to date, the existence of TD enteroviral populations have not been documented in any other organ …