作者
Jennifer L Dickson, Kent W Stewart, Christopher G Pretty, Marine Flechet, Thomas Desaive, Sophie Penning, Bernard C Lambermont, Balázs Benyó, Geoffrey M Shaw, J Geoffrey Chase
发表日期
2017/3/24
期刊
IEEE transactions on biomedical engineering
卷号
65
期号
7
页码范围
1543-1553
出版商
IEEE
简介
Background
Elevated blood glucose (BG) concentrations (Hyperglycaemia) are a common complication in critically ill patients. Insulin therapy is commonly used to treat hyperglycaemia, but metabolic variability often results in poor BG control and low BG (hypoglycaemia).
Objective
This paper presents a model-based virtual trial method for glycaemic control protocol design, and evaluates its generalisability across different populations.
Methods
Model-based insulin sensitivity (SI) was used to create virtual patients from clinical data from three different ICUs in New Zealand, Hungary, and Belgium. Glycaemic results from simulation of virtual patients under their original protocol (self-simulation) and protocols from other units (cross simulation) were compared.
Results
Differences were found between the three cohorts in median SI and inter-patient variability in SI. However, hour-to-hour intra-patient variability in SI was …
学术搜索中的文章
JL Dickson, KW Stewart, CG Pretty, M Flechet… - IEEE transactions on biomedical engineering, 2017