作者
Milo Frattini, Cristina Ferrario, Paola Bressan, Debora Balestra, Loris De Cecco, Piera Mondellini, Italia Bongarzone, Paola Collini, Manuela Gariboldi, Silvana Pilotti, Marco A Pierotti, Angela Greco
发表日期
2004/9
期刊
Oncogene
卷号
23
期号
44
页码范围
7436-7440
出版商
Nature Publishing Group
简介
Papillary thyroid carcinoma (PTC) is associated with RET and NTRK1 rearrangements and BRAF mutations. A series of 60 PTCs collected in a single center from Italian patients were histologically re-examined and subclassified as well differentiated or tall cell variant. The sample collection was analysed for the presence of all the reported PTC-associated genetic alterations through DNA or cDNA amplification, followed by automated sequencing. The analysis of exons 11 and 15 of BRAF gene revealed the T1796A (V599E) mutation in 32% of cases, and this alteration is significantly associated with PTC tall cell variant. Oncogenic rearrangements of RET and NTRK1 receptors were found in 33 and 5% of cases, respectively. No Ras mutations were detected. Overall, genetic alterations were detected in two-thirds of samples, and in no single case more than one mutational event was found simultaneously. Gene …
引用总数
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M Frattini, C Ferrario, P Bressan, D Balestra… - Oncogene, 2004