作者
Jasminka Krištić, Frano Vučković, Cristina Menni, Lucija Klarić, Toma Keser, Ivona Beceheli, Maja Pučić-Baković, Mislav Novokmet, Massimo Mangino, Kujtim Thaqi, Pavao Rudan, Natalija Novokmet, Jelena Šarac, Saša Missoni, Ivana Kolčić, Ozren Polašek, Igor Rudan, Harry Campbell, Caroline Hayward, Yurii Aulchenko, Ana Valdes, James F Wilson, Olga Gornik, Dragan Primorac, Vlatka Zoldoš, Tim Spector, Gordan Lauc
发表日期
2014/7/1
期刊
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
卷号
69
期号
7
页码范围
779-789
出版商
Oxford University Press
简介
Fine structural details of glycans attached to the conserved N-glycosylation site significantly not only affect function of individual immunoglobulin G (IgG) molecules but also mediate inflammation at the systemic level. By analyzing IgG glycosylation in 5,117 individuals from four European populations, we have revealed very complex patterns of changes in IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, and FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus, IgG glycosylation appears to be closely linked with both chronological and biological ages. Considering the important role of IgG glycans …
学术搜索中的文章
J Krištić, F Vučković, C Menni, L Klarić, T Keser… - Journals of Gerontology Series A: Biomedical Sciences …, 2014