作者
Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Peter Höller, Piergiorgio Lochner, Stefan Golaszewski, Francesco Brigo, Eugen Trinka
发表日期
2015/2
来源
Journal of neural transmission
卷号
122
页码范围
279-295
出版商
Springer Vienna
简介
Changes in descending serotonergic innervation of spinal neural activity have been implicated in symptoms of paralysis, spasticity, sensory disturbances and pain following spinal cord injury (SCI). Serotonergic neurons possess an enhanced ability to regenerate or sprout after many types of injury, including SCI. Current research suggests that serotonine (5-HT) release within the ventral horn of the spinal cord plays a critical role in motor function, and activation of 5-HT receptors mediates locomotor control. 5-HT originating from the brain stem inhibits sensory afferent transmission and associated spinal reflexes; by abolishing 5-HT innervation SCI leads to a disinhibition of sensory transmission. 5-HT denervation supersensitivity is one of the key mechanisms underlying the increased motoneuron excitability that occurs after SCI, and this hyperexcitability has been demonstrated to underlie the pathogenesis …
引用总数
20152016201720182019202020212022202320242362835932
学术搜索中的文章
R Nardone, Y Höller, A Thomschewski, P Höller… - Journal of neural transmission, 2015