作者
Lindsey P Koliscak, James W Johnson, James R Beardsley, David P Miller, John C Williamson, Vera P Luther, Christopher A Ohl
发表日期
2013/12
期刊
Antimicrobial agents and chemotherapy
卷号
57
期号
12
页码范围
5918-5923
出版商
American Society for Microbiology
简介
Antibiotic selection is challenging in patients with severe β-lactam allergy due to declining reliability of alternate antibiotics. Organisms isolated from these patients may exhibit unique resistance phenotypes. The objective of this study was to determine which alternate antibiotics or combinations provide adequate empirical therapy for patients with β-lactam allergy who develop Gram-negative infections at our institution. We further sought to determine the effects of risk factors for drug resistance on empirical adequacy. A retrospective analysis was conducted for adult patients hospitalized from September 2009 to May 2010 who had a severe β-lactam allergy and a urine, blood, or respiratory culture positive for a Gram-negative organism and who met predefined criteria for infection. Patient characteristics, culture and susceptibility data, and predefined risk factors for antibiotic resistance were collected. Adequacies of β …
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LP Koliscak, JW Johnson, JR Beardsley, DP Miller… - Antimicrobial agents and chemotherapy, 2013